Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

Fei Mo,Xiaoxuan Zhuang,Xing Liu,Phil Y Yao,Bo Qin,Zeqi Su,Jianye Zang,Zhiyong Wang,Jiancun Zhang,Zhen Dou,Changlin Tian,Maikun Teng,Liwen Niu,Donald L Hill,Guowei Fang,Xia Ding,Chuanhai Fu,Xuebiao Yao

NATURE CHEMICAL BIOLOGY（2016）

引用 71|浏览15

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摘要

The cell cycle regulator CDK1 phosphorylates the acetyltransferase TIP60, which subsequently acetylates the mitotic regulator Aurora B to ensure chromosomal segregation. Aurora B acetylation prevents inactivation by PP2A-mediated dephosphorylation.

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关键词

Small molecules,Cell division,Post-translational modifications,DNA damage and repair

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