CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

NATURE MEDICINE（2016）

引用 177|浏览20

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摘要

Expression of HNF1A and KRT81 stratifies pancreatic ductal adenocarcinoma tumors into different subtypes, and expression of cytochrome P450 3A5 mediates basal and/or drug-induced therapy resistance in each subtype.

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关键词

Cancer models,Cancer metabolism,Pancreatic cancer,Prognostic markers,Cancer therapeutic resistance

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