NAFLD causes selective CD4 + T lymphocyte loss and promotes hepatocarcinogenesis

NATURE（2016）

引用 623|浏览21

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摘要

Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4 + T cells, leading to impaired anti-tumour immunity.

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关键词

Non-alcoholic fatty liver disease,Immunosurveillance,Liver cancer,Immune cell death,Fatty acids

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