A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

Lisa D Cabrita,Anaïs M E Cassaignau,Hélène M M Launay,Christopher A Waudby,Tomasz Wlodarski,Carlo Camilloni,Maria-Evangelia Karyadi,Amy L Robertson,Xiaolin Wang,Anne S Wentink, Luke S Goodsell,Cheryl A Woolhead,Michele Vendruscolo,Christopher M Dobson,John Christodoulou

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

Cited 112|Views12

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Abstract

NMR approaches are used to probe cotranslational folding of a nascent polypeptide with two domains in Escherichia coli . The work reveals that interactions with the ribosome inhibit acquisition of the native fold by the nascent chain.

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Key words

Solution-state NMR,Protein folding,Ribosome

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