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A molecular threshold for effector CD8 + T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Annie Xin,Frederick Masson,Yang Liao,Simon Preston,Tianxia Guan,Renee Gloury,Moshe Olshansky,Jian-Xin Lin,Peng Li,Terence P Speed,Gordon K Smyth,Matthias Ernst,Warren J Leonard,Marc Pellegrini,Susan M Kaech,Stephen L Nutt, Wei Shi,Gabrielle T Belz,Axel Kallies

NATURE IMMUNOLOGY（2016）

Cited 187|Views6
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Abstract
Using genetic approaches and transcriptional profiling, Kallies and colleagues reveal a common program of effector CD8 + T cell differentiation that is regulated by the cooperation of IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
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Key words
T cells,Gene regulation in immune cells
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