A conditional proteomics approach to identify proteins involved in zinc homeostasis
NATURE METHODS(2016)
摘要
‘conditional proteomics’ approach, as applied here to identify proteins involved in zinc homeostasis, utilizes an activatable labeling reagent to tag proteins affected by a particular biological condition in the cell, enabling them to be isolated and identified using mass spectrometry.
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关键词
Metals,Cell signalling,Proteomic analysis,Proteomics,Chemical tools
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