A conditional proteomics approach to identify proteins involved in zinc homeostasis

NATURE METHODS(2016)

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摘要
‘conditional proteomics’ approach, as applied here to identify proteins involved in zinc homeostasis, utilizes an activatable labeling reagent to tag proteins affected by a particular biological condition in the cell, enabling them to be isolated and identified using mass spectrometry.
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关键词
Metals,Cell signalling,Proteomic analysis,Proteomics,Chemical tools
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