Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

NATURE CELL BIOLOGY(2016)

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摘要
By engineering mice to express a version of the Pten tumour suppressor that lacks the three C-terminal amino acids, van Deursen and colleagues reveal a role for the protein in the generation of symmetric spindles through recruitment of Eg5 to centrosomes.
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关键词
Mitotic spindle,Chromosome segregation,Cancer
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