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An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior

Yonwoo Jung,Lawrence S Hsieh,Angela M Lee,Zhifeng Zhou,Daniel Coman,Christopher J Heath,Fahmeed Hyder,Yann S Mineur,Qiaoping Yuan,David Goldman,Angelique Bordey,Marina R Picciotto

NATURE NEUROSCIENCE（2016）

Cited 73|Views6
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Abstract
Developmental nicotine exposure increased cortical dendritic complexity, levels of Ash2l and Mef2c (components of a histone methyltransferase complex), and H3MeK4 trimethylation at promoters of genes involved in synapse maintenance. Knockdown and overexpression experiments in utero showed that Ash2l and Mef2c regulate nicotine-mediated dendritic remodeling and changes in passive avoidance behavior.
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Key words
Molecular neuroscience,Neuronal development,Epigenetics and behaviour,Developmental disorders,Histone post-translational modifications
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