Human commensals producing a novel antibiotic impair pathogen colonization
NATURE(2016)
Abstract
The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly reduced S. aureus carriage rate in humans, suggesting that human commensal bacteria could be a valuable resource for the discovery of new antibiotics.
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Key words
Antibiotics,Pathogens,Peptides,Science,Humanities and Social Sciences,multidisciplinary
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