Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

Wilfredo F Garcia-Beltran,Angelique Hölzemer,Gloria Martrus,Amy W Chung,Yovana Pacheco,Camille R Simoneau,Marijana Rucevic,Pedro A Lamothe-Molina,Thomas Pertel,Tae-Eun Kim,Haley Dugan,Galit Alter,Julie Dechanet-Merville,Stephanie Jost,Mary Carrington,Marcus Altfeld

Nature Immunology（2016）

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摘要

The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease.

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关键词

HIV infections,Innate immunity,NK cells,Biomedicine,general,Immunology,Infectious Diseases

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