Cellularly active N -hydroxyurea FEN1 inhibitors block substrate entry to the active site

Jack C Exell,Mark J Thompson,L David Finger,Steven J Shaw,Judit Debreczeni,Thomas A Ward,Claire McWhirter,Catrine L B Siöberg,Daniel Martinez Molina,W Mark Abbott,Clifford D Jones,J Willem M Nissink,Stephen T Durant,Jane A Grasby

Nature chemical biology（2016）

引用 52|浏览16

暂无评分

摘要

Structural, enzymatic and cellular target engagement studies reveal the mechanism of action by N -hydroxyurea small molecule inhibitors of the DNA repair enzyme, human flap endonuclease-1 (FEN1) that prevent cleavage of DNA flaps in cancer cells.

查看译文

关键词

Enzyme mechanisms,DNA damage and repair,X-ray crystallography,Small molecules

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要