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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Nicholas A Feasey,James Hadfield,Karen H Keddy,Timothy J Dallman,Jan Jacobs,Xiangyu Deng,Paul Wigley,Lars Barquist,Gemma C Langridge,Theresa Feltwell,Simon R Harris,Alison E Mather,Maria Fookes,Martin Aslett,Chisomo Msefula,Samuel Kariuki,Calman A Maclennan,Robert S Onsare,François-Xavier Weill,Simon Le Hello,Anthony M Smith,Michael McClelland,Prerak Desai,Christopher M Parry,John Cheesbrough,Neil French,Josefina Campos,Jose A Chabalgoity,Laura Betancor,Katie L Hopkins,Satheesh Nair,Tom J Humphrey,Octavie Lunguya,Tristan A Cogan,Milagritos D Tapia,Samba O Sow,Sharon M Tennant,Kristin Bornstein,Myron M Levine,Lizeth Lacharme-Lora,Dean B Everett,Robert A Kingsley,Julian Parkhill,Robert S Heyderman,Gordon Dougan,Melita A Gordon,Nicholas R Thomson

Nature Genetics（2016）

Cited 154|Views17
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Abstract
Nicholas Feasey and colleagues report whole-genome sequence analysis of 675 isolates of Salmonella enterica serovar Enteritidis from 45 countries. They find evidence for a global epidemic clade associated with enterocolitis and two novel clades restricted to distinct regions of Africa and associated with invasive disease.
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Key words
Bacterial infection,Genomics,Microbial genetics,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics
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