Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akçay,Matthew A Belmonte,Brian Aquila,Claudio Chuaqui,Alexander W Hird,Michelle L Lamb,Philip B Rawlins,Nancy Su,Sharon Tentarelli,Neil P Grimster,Qibin Su

NATURE CHEMICAL BIOLOGY（2016）

引用 120|浏览18

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摘要

The use of an aryl boronic acid carbonyl warhead to target a noncatalytic lysine side chain enables the development of covalent inhibitors against the anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1).

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关键词

Cell death,Small molecules,Post-translational modifications,Medicinal chemistry

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