Small-molecule WNK inhibition regulates cardiovascular and renal function
Ken Yamada,Hyi-Man Park,Dean F Rigel,Keith DiPetrillo, Erin J Whalen,Anthony Anisowicz,Michael Beil,James Berstler,Cara Emily Brocklehurst,Debra A Burdick,Shari L Caplan,Michael P Capparelli,Guanjing Chen,Wei Chen,Bethany Dale,Lin Deng,Fumin Fu,Norio Hamamatsu, Kouki Harasaki, Tracey Herr,Peter Hoffmann,Qi-Ying Hu,Waan-Jeng Huang,Neeraja Idamakanti, Hidetomo Imase,Yuki Iwaki,Monish Jain, Jey Jeyaseelan,Mitsunori Kato,Virendar K Kaushik,Darcy Kohls,Vidya Kunjathoor,Daniel LaSala, Jongchan Lee,Jing Liu, Yang Luo,Fupeng Ma, Ruowei Mo, Sarah Mowbray,Muneto Mogi,Flavio Ossola,Pramod Pandey,Sejal J Patel, Swetha Raghavan,Bahaa Salem, Yuka H Shanado, Gary M Trakshel,Gordon Turner, Hiromichi Wakai,Chunhua Wang, Stephen Weldon, Jennifer B Wielicki,Xiaoling Xie,Lingfei Xu,Yukiko I Yagi, Kayo Yasoshima, Jianning Yin,David Yowe,Ji-Hu Zhang, Gang Zheng,Lauren Monovich NATURE CHEMICAL BIOLOGY（2016）
Abstract
selective inhibitor of the With-No-Lysine (K) (WNK) kinase family reduces blood pressure and increases electrolyte excretion in hypertensive rats.
MoreTranslated text
Key words
Kinases,X-ray crystallography,Small molecules,Cardiovascular diseases
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
