Increased IL-10/IL-17 ratio is aggravated along with the prognosis of patients with chronic lymphocytic leukemia.

Nannan Pang,Rui Zhang,Jinhua Li,Zhenghao Zhang,Hailong Yuan,Gang Chen,Fang Zhao,Lei Wang,Haizhou Cao,Jianhua Qu,Jianbing Ding

International Immunopharmacology（2016）

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摘要

•Treg and Th17 cell counts are increased in peripheral blood in the CLL patients.•Serum levels of IL-10 and IL-17 and IL-10/IL-17 ratio are increased in CLL patients.•Foxp3 and RORγt expression levels are up-regulated in the CLL patients.•Treg/Th17 ratio is lowered in CLL patients in remission after treatment.•Higher IL-10/IL-17 ratio is associated with poorer prognosis of CLL.

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关键词

Chronic lymphocytic leukemia (CLL),Regulatory T (Treg) cells,Th17 cells,IL-10,IL-17

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