H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

Giulia Saredi,Hongda Huang,Colin M. Hammond,Constance Alabert,Simon Bekker-Jensen,Ignasi Forne,Nazaret Reverón-Gómez,Benjamin M. Foster,Lucie Mlejnkova,Till Bartke,Petr Cejka,Niels Mailand,Axel Imhof,Dinshaw J. Patel,Anja Groth

Nature（2016）

引用 196|浏览45

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摘要

We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.

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关键词

Histone post-translational modifications,X-ray crystallography

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