A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Daniel Dauch,Ramona Rudalska,Giacomo Cossa,Jean-Charles Nault,Tae-Won Kang,Torsten Wuestefeld,Anja Hohmeyer,Sandrine Imbeaud,Tetyana Yevsa,Lisa Hoenicke,Tatu Pantsar,Przemyslaw Bozko,Nisar P Malek,Thomas Longerich,Stefan Laufer,Antti Poso,Jessica Zucman-Rossi,Martin Eilers,Lars Zender

NATURE MEDICINE（2016）

引用 208|浏览46

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摘要

In Trp53 -mutated hepatocellular carcinoma, conformation-changing aurora kinase A inhibitors disrupt aurora kinase A–MYC interactions, resulting in MYC degradation and suppression of tumor growth.

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关键词

Liver cancer,Targeted therapies

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