Developing artificial neural network models to predict functioning one year after traumatic spinal cord injury.

To develop mathematical models for predicting level of independence with specific functional outcomes one year after discharge from inpatient rehabilitation for spinal cord injury.Statistical analyses using artificial neural networks and logistic regression.Retrospective analysis of data from the national, multicenter Spinal Cord Injury Model Systems Database (NSCID).Subjects (N=3,142; Mean age = 41.5 years) with traumatic spinal cord injury who contributed data for NSCID longitudinal outcomes studies.Self-reported ambulation ability, and Functional Independence Measure derived indices of level of assistance required for self-care activities (i.e., bed-chair transfers, bladder and bowel management, eating, and toileting).Models for predicting ambulation status were highly accurate (exceeding 85% case classification accuracy; areas under the receiver operating characteristic curve between 0.86 and 0.90). Models for predicting non-ambulation outcomes were moderately accurate (76% to 86% case classification accuracy; areas under the receiver operating characteristic curve between 0.70 and 0.82). The performance of models generated by artificial neural networks closely paralleled the performance of models analyzed using logistic regression constrained by the same independent variables.After further prospective validation, such predictive models may allow clinicians to use data available at the time of admission to inpatient spinal cord injury rehabilitation to accurately predict longer-term ambulation status, and whether or not individual patients are likely to perform various self-care activities with or without assistance from another person.