Tuning the reactivity of Sp1 zinc fingers with platinum complexes.

Zhifeng Du,Raphael E F de Paiva,Yun Qu,Nicholas Farrell

DALTON TRANSACTIONS（2016）

引用 12|浏览0

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摘要

cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}(2)-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.

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