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HLA-C Downmodulation by HIV-1 Vpu.

Edward Barker,David T Evans

Cell Host & Microbe（2016）

Cited 7|Views12
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Abstract
It is widely held that HIV-1 Nef downmodulates HLA-A and -B to protect infected cells from CD8(+) T cells but leaves HLA-C on the cell surface to inhibit NK cells. In this issue of Cell Host & Microbe, Apps et al. (2016) revise this model by showing that the Vpu protein of primary HIV-1 isolates downmodulate HLA-C.
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