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Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.

Chunhe Su,Xiaopeng Yang,Jiyu Lou

Brain Research（2016）

Cited 56|Views16
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Abstract
•MicroRNA-21 participates in the neuroprotective effect of geniposide in Parkinson's disease.•MicroRNA-21 enhances α-synuclein expression via targeting LAMP2A.•Geniposide promotes LAMP2A and inhibits in α-synuclein Parkinson's disease.•We found a potential mechanism underlying the neuroprotective effect of geniposide.
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Key words
Geniposide,Parkinson disease,MiR-21,LAMP2A,α-synuclein
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