Electrochemically Gated Graphene Field-Effect Transistor for Extracellular Cell Signal Recording.

This work presents an experimental characterization of electrochemically gated graphene field-effect transistors (EGFETs) to measure extracellular cell signals. The performance of the EGFETs was evaluated using cardiomyocytes cells. Extracellular signals with a peak value of 0.4 pico-amperes (pA) embedded in a noise level of 0.1 pA were recorded. Signals in current mode were compared with signals recorded as a voltage. Signals below 28 mu V of magnitude can be detected in a noise floor of 7 mu V with a signal-to-noise ratio of 4.