A Semi-Automated Method For Measuring The Evolution Of Both Lumen Area And Blood Flow In Carotid From Phase Contrast Mri
COMPUTERS IN BIOLOGY AND MEDICINE(2015)
Abstract
Phase-Contrast (PC) velocimetry Magnetic Resonance Imaging (MRI) is a useful modality to explore cardiovascular pathologies, but requires the automatit segmentation of vessels and the measurement of both lumen area and blood flow evolutions. In this paper, we propose a semi-automated method for extracting lumen boundaries of the carotid artery and compute both lumen area and blood flow evolutions over the cardiac cycle. This method uses narrow band region-based active contours in order to correctly capture the lumen boundary without being corrupted by surrounding structures. This approach is compared to traditional edge-based active contours, considered in related works, which significantly underestimate lumen area and blood flow. Experiments are performed using both a sequence of a homemade phantom and sequences of 20 real carotids, including a comparison with manual segmentation performed by a radiologist expert. Results obtained on the phantom sequence show that the edgebased approach leads to an underestimate of carotid lumen area and related flows of respectively 18.68% and 4.95%. This appears significantly larger than weak errors obtained using the region-based approach (respectively 2.73% and 1.23%). Benefits appear even better on the real sequences. The edge-based approach leads to underestimates of 40.88% for areas and 13.39% for blood flows, compared to limited errors of 7.41% and 4.6% with our method. Experiments also illustrate the high variability and therefore the lack of reliability of manual segmentation. (C) 2015 Elsevier Ltd. All rights reserved.
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Key words
Semi-automated analysis,Region-based active contour,Blood flow,Magnetic Resonance Imaging,Phantom
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