A multi-objective multi-drug model for cancer chemotherapy treatment planning: A cost-effective approach to designing clinical trials.

•A multi-objective multi-drug optimization model for cancer chemotherapy treatment planning is developed.•The proposed optimization strategy provides a reasonable trade-off between the survival time and treatment costs.•The proposed multi-objective optimization approach can generate the most promising low cost drug combinations.•The proposed approach gives an efficient tool to the oncologists for designing the clinical trials.