Bone quality assessed using quantitative ultrasound at the distal radius does not differ in antiretroviral therapy-naïve HIV-positive and HIV-negative Rwandan women.
HIV MEDICINE(2016)
摘要
Objectives The incidence of fractures appears to be increased in HIV-infected individuals. Methods We assessed bone quality using quantitative ultrasound (QUS) in HIV-infected and uninfected Rwandan women. A Sunlight Omnisense 7000 QUS was used to measure the speed of ultrasound (SOS) at the distal radius in 646 antiretroviral therapy (ART)-naive HIV-infected women and 211 HIV-uninfected women. The Z-scores for SOS were based on data for women of the same age from the manufacturer's reference material. Results The mean CD4 cell count was 285 (+/- 166) cells/mu L in the HIV-positive women. SOS Z-scores adjusted and unadjusted for body mass index did not differ between the groups. SOS did not differ by CD4 count (< 200 vs. >= 200 cells/mu L: 4016 (+/- 117) vs. 4028 (+/- 107) m/s, respectively; p=0.19. Conclusions In HIV-positive ART-naive Rwandan women with advanced HIV disease, bone quality at the distal radius was similar to that in HIV-negative controls.
更多查看译文
关键词
antiretroviral therapy,antiretroviral therapy-naive,bone mineral density,HIV,women
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络