Application of reporter strains for new antibiotic screening]

P V Sergiev,I A Osterman,A Ya Golovina,I G Laptev,P I Pletnev,S A Evfratov,E I Marusich,S V Leonov,Ya A Ivanenkov,A A Bogdanov,O A Dontsova

Biomeditsinskaia khimiia（2016）

Cited 6|Views30

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Abstract

Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure.Abstract available from the publisher.

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Key words

antibiotic,bacteria,protein synthesis,reporter strain,screening

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