Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

Tomoya Fukawa, Benjamin Chua Yan-Jiang, Jason Chua Min-Wen,Elwin Tan Jun-Hao,Dan Huang,Chao-Nan Qian,Pauline Ong,Zhimei Li,Shuwen Chen,Shi Ya Mak,Wan Jun Lim,Hiro-omi Kanayama,Rosmin Elsa Mohan,Ruiqi Rachel Wang, Jiunn Herng Lai,Clarinda Chua,Hock Soo Ong,Ker-Kan Tan,Ying Swan Ho,Iain Beehuat Tan,Bin Tean Teh,Ng Shyh-Chang

NATURE MEDICINE（2016）

引用 164|浏览36

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摘要

Cachexia-inducing tumors release complex factors that promote the increased uptake and burning of fats by muscle, resulting in muscle atrophy—a process that can be blocked if fatty acid oxidation is pharmacologically inhibited.

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关键词

Microarrays,Metabolic disorders,Cancer models

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