Simultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration.
Journal of Chromatography B（2016）
Abstract
•We determined parecoxib and its active metabolite valdecoxib in rat plasma.•The prodrug parecoxib was immediately converted to the active drug valdecoxib.•Muscle injection gets similar intravenous conversion rate of parecoxib to valdecoxib.
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Key words
Parecoxib sodium,Valdecoxib,UPLC–MS/MS,Pharmacokinetics,Metabolite,Rat plasma
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