Fiber knob domain lacking the shaft sequence but fused to a coiled coil is a candidate subunit vaccine against egg-drop syndrome.
Vaccine(2016)
Abstract
•Egg-drop syndrome virus fiber knob domain was fused to trimeric coiled coils.•Single immunization of chickens with the fusion proteins elicited antibodies with high hemagglutination inhibition activities.•Immunization protected laying hens from clinical symptoms of EDS.
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Key words
CELO,CMP,EDS,HMM,TCID50
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