PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia.

•Combined PLAG and pegfilgrastim is more effective in gemcitabine-induced neutropenia than pegfilgrastim alone.•PLAG had no effect on neutrophil counts in the bone marrow or on neutrophil apoptosis.•Pegfilgrastim-induced CXCR2 expression in neutrophils was markedly decreased in the group also treated with PLAG.