2'-Modified Guanosine Analogs for the Treatment of HCV.

Vinay Girijavallabhan,Ashok Arasappan,Frank Bennett,Kevin Chen,Qun Dang,Ying Huang,Angela Kerekes,Latha Nair,Dmitri Pissarnitski,Vishal Verma,Carmen Alvarez, Ping Chen,David Cole, Sara Esposite,Yuhua Huang,Qingmei Hong, Zhidan Liu,Weidong Pan,Haiyan Pu,Randall Rossman, Quang Truong,Bancha Vibulbhan, Jun Wang,Zhiqiang Zhao,David Olsen,Andrew Stamford,Stephane Bogen,F George Njoroge

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2016）

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摘要

Novel 2'-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7-10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2'-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5'-O-triphosphates (compounds 38-44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.

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