Rna Polymerase Ii Acts As A Selective Sensor For Dna Lesions And Endogenous Dna Modifications
TRANSCRIPTION-AUSTIN(2016)
Abstract
During transcription elongation, RNA polymerase II (pol II) travels along the DNA template across thousands to millions of nucleotides and accurately synthesizes the complementary RNA transcripts. Apart from its canonical function as a key enzyme for DNA-dependent RNA synthesis, pol II also functions as a selective sensor to recognize DNA lesions or epigenetic modifications.
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Key words
DNA lesions, DNA modifications, epi-DNA recognition loop, RNA polymerase II, sensor
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