Doxorubicin and cyclophosphamide lead to long-lasting impairment of spatial memory in female, but not male mice.

•Female mice exhibit deficits in spatial memory when exposed to doxorubicin and cyclophosphamide.•The spatial memory of male mice is not affected by exposure to doxorubicin and cyclophosphamide.•Spatial memory deficits in females persist following exposure to chemotherapeutic agents.