Excretory/secretory products of adult Haemonchus contortus and Teladorsagia circumcincta which increase the permeability of Caco-2 cell monolayers are neutralised by antibodies from immune hosts.

Z U Rehman,Q Deng,S Umair,M S Savoian,J S Knight,A Pernthaner,H V Simpson

Veterinary Parasitology（2016）

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摘要

•ES products of H. contortus and T. circumcincta reduced TEER of Caco-2 cell monolayers.•Zona occludens-1 and occludin were internalised from disrupted junctions after exposure to ES products.•Increase in TEER partially blocked by phage displaying single chain antibodies derived from immune sheep and enriched by panning with H. contortus ES products.

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关键词

Haemonchus contortus,Teladorsagia circumcincta,ES products,Caco-2 cell TEER,Epithelial permeability,Phage display,Single chain antibodies

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