A Functional Variant rs6435156C > T in BMPR2 is Associated With Increased Risk of Chronic Obstructive Pulmonary Disease (COPD) in Southern Chinese Population.

Jian Wang,Chenting Zhang,Zili Zhang,Zeguang Zheng,Dejun Sun,Quan Yang,Cyrus Hadadi,Defu Li,Xiaoming Xu,Mingmei Xiong,Qipeng Zhou,Meihua Guo,Yingfeng Wang,Chun Tang,Guihua Xu,Kai Yang,Nanshan Zhong,Wenju Lu

EBioMedicine（2016）

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摘要

•The rs6435156 TT was associated with greater risk of COPD in smokers than in non-smokers.•Cigarette smokers with rs6435156 TT were more susceptible to COPD than those with CC genotype.•The T genotype of rs6435156 inhibited BMPR2 expression in PBMCs and lung epithelial cells.•The rs6435156 T is the functional binding site for miR-20a.

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关键词

COPD,BMPR2,rs6435156,Cigarette smoking,hsa-miR-20a

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A Functional Variant rs6435156C &gt; T in BMPR2 is Associated With Increased Risk of Chronic Obstructive Pulmonary Disease (COPD) in Southern Chinese Population.

A Functional Variant rs6435156C > T in BMPR2 is Associated With Increased Risk of Chronic Obstructive Pulmonary Disease (COPD) in Southern Chinese Population.