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Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

Rieko Okada,Mariko Naito,Yuta Hattori,Toshio Seiki,Kenji Wakai,Hinako Nanri,Miki Watanabe,Sadao Suzuki,Tara Sefanya Kairupan,Naoyuki Takashima,Haruo Mikami,Keizo Ohnaka,Yoshiyuki Watanabe,Sakurako Katsuura-Kamano,Michiaki Kubo,Nobuyuki Hamajima,Hideo Tanaka, The Japan Multi-institutional Collaborative Cohort Study Group

Gastric Cancer（2017）

Cited 15|Views24
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Abstract
A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes.
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Key words
MMP9,Genetic polymorphism,Gastric cancer,Family history,Epidemiology
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