Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity.

Background: We aimed to examine the associations of adipocytokines and circulating bone metabolism markers with bone mineral parameters in early pubertal boys with different physical activity level. Methods: Eighty-six early pubertal boys were divided into active and non-active boys according to the accumulated moderate-to-vigorous physical activity (MVPA) level. Body composition and bone mineral parameters were assessed and testosterone, leptin, adiponectin, osteocalcin (OC), and C-terminal telopeptide of type I collagen (CTX) were measured. Results: Active subjects had significantly lower (p < 0.05) body mass, body mass index (BMI), fat mass (FM), leptin, and sedentary time values, while non-active subjects had lower (p < 0.05) vigorous physical activity level and femoral neck bone mineral density (FN-BMD). OC contributed to the models in physically active group and explained 6.6% and 9.7% of variance in whole body (WB) [F(5,44) = 10.847; p < 0.001] and lumbar spine bone mineral content (LS-BMC) [F(5,44) = 4.158; p = 0.004], respectively. No other biochemical parameters were found to be related to bone mineral parameters in either the active or nonactive group. Conclusions: Bone metabolism markers were positively correlated with bone mineral values only in active pubertal boys. Leptin and adiponectin were not related to bone mineral parameters in active and non-active pubertal boys.