Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein.

Jishen Pan,Elizabeth Sinclair,Zhuoli Xuan,Marcin Dyba,Ying Fu,Supti Sen,Deborah Berry,Karen Creswell, Jiaxi Hu,Rabindra Roy,Fung-Lung Chung

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2016）

Cited 10|Views31

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Abstract

•NER-deficiency induces elevated apoptosis and Acr-dG in cells treated with DHA.•XPA knockdown increases acrolein induced apoptosis and Acr-dG levels in cells.•Increased Acr-dG levels are correlated with high levels of apoptosis.•Acr-dG formation may contribute to the apoptotic potency of DHA.

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Key words

DNA adduct,Docosahexaenoic acid,Acrolein,Nucleotide excision repair,Apoptosis

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