Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

•Axonal and NMJ pathology is present over the SOD1G93A disease time-course.•NMJ morphology and branching alteration occurs prior to symptom onset.•NMJ architectural proteins are lost from the postsynaptic density.•NMJ architectural protein levels are increase and possibly misprocessed.