Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation.

•AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages.•AIBP prevents ABCA1 from CSN2-mediated degradation to prevent foam cell formation.•AIBP 115–123 aa is at least partially responsible for its binding to apoA-1.