Failure of primary atovaquone prophylaxis for prevention of toxoplasmosis in hematopoietic cell transplant recipients.

K Gajurel,C A Gomez, R Dhakal,H Vogel,J G Montoya

TRANSPLANT INFECTIOUS DISEASE（2016）

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摘要

The efficacy of primary prophylaxis with atovaquone in preventing Toxoplasma reactivation and disease in hematopoietic cell transplant (HCT) recipients is unknown. We describe 2 cases of atovaquone prophylaxis failure in pre-HCT Toxoplasma-seropositive (pre-HCTSP) recipients who underwent allogeneic HCT (allo-HCT) and review the literature on atovaquone prophylaxis in HCT recipients.

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关键词

atovaquone,hematopoietic cell transplant,preemptive treatment,prophylaxis,Toxoplasma,toxoplasmosis

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