Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target.

•Typical 2-Cys peroxiredoxins play several functions in eukarya.•In parasites peroxidase and holdase activities of Prx1 family are correlated with virulence.•The possibility to inhibit one function over the others is a foreseeable task.•Due to active site conservation in Prx1 family, synthesis of specific inhibitors is challenging.