Use of Paclitaxel-Coated Balloon Catheter Dilation to Reduce In-Stent Restenosis in Transjugular Intrahepatic Portosystemic Shunt (TIPS).
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN(2016)
Abstract
Purpose: Paclitaxel-coated balloons (PCB) inhibit neointimal proliferation in arteries. The purpose of this retrospective analysis was to investigate the effect of PCB in in-stent restenosis after trans jugular intrahepatic portosystemic shunt (TIPS) in patients with cirrhotic liver disease. Materials and Methods: Six patients (mean age: 65 10 years) with recurrent in-stent restenoses in TIPS (5 bare stems, 1 covered stent) underwent a single percutaneous transluminal angioplasty (PTA) with PCB (3 pg paclitaxel/mm(2)). Post-interventional outcome and patency were compared with those of prior plain optimal balloon angioplasty (POBA) in the same patients. During a twoyear follow-up period, all patients underwent angiographic examinations at 6 -month intervals. In-stent minimal lumen diameter (MILD) and late lumen loss (LLL) were assessed. Paclitaxel residues on balloon and sheath surfaces as well as venous plasma concentrations (0 - 24 hours) were analyzed. Results: PCB decreased the need for clinically driven repeat PTA (POBA: 53% of angiographic examinations; paclitaxel PTA: 19 %; P =0.014). LLL/diameter stenosis was higher after POBA (2.4 1.5 mm/28 18%) than after PCB (0.5 0.8 mm/7 +/- 11%, P = 0.029). Residual paclitaxel on balloons was '28 +/- 9 % of dose and 0.2 +/- 0.1% on sheath surfaces. Paclitaxel plasma concentrations were below detectable levels throughout the first 24 hours after the interventions in all patients. The procedure was well tolerated and no clinical side effects attributable to paclitaxel were observed. Conclusion: In patients with recurrent in-stent stenoses, a single PTA with PCB resulted in a prolonged secondary patency due to pseudointimahy-perplasia without a systemic effect of paclitaxel.
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Key words
portosystemic shunt,lransjugular intrahepatic balloon angioplasty,paclitaxel
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