Cancer Imaging: pH-Activatable MnO-Based Fluorescence and Magnetic Resonance Bimodal Nanoprobe for Cancer Imaging (Adv. Healthcare Mater. 6/2016).

Hsu Benedict You Wei,Ng Michael,Tan Aaron,Connell John,Roberts Thomas, Lythgoe Mark,Zhang Yu,Wong Siew Yee,Bhakoo Kishore,Seifalian Alexander M,Li Xu,Wang John

Advanced healthcare materials（2016）

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摘要

On page 721, X. Li, J. Wang, and co-workers report on a MnO-based fluorescence/MRI dual-modality nanoprobe for cancer imaging. While the encapsulated MnO nanoparticles can quench the fluorophores effectively prior to cellular uptake, fluorescence activation is triggered upon dissolution of the MnO nanoparticles to release Mn(2+) ions in the acidic lysosomal compartment of the cancer cells.

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关键词

MRI,cancer imaging,coumarin,manganese oxide,pH-responsive

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