Pomegranate protects liver against cecal ligation and puncture-induced oxidative stress and inflammation in rats through TLR4/NF-κB pathway inhibition.

•Pomegranate has antiinflammatory and antioxidant effects on CLP-acute liver injury.•Pomegranate has ability to inhibit TLR4/NF‐κB pathway and neutrophil infiltration.•Pomegranate has ability to modulate lipid peroxidation and antioxidants levels.