Synthesis, Characterization, And Dna Binding Properties Of Dinuclear Copper(Ii) Complex [Cu-2(Tatp)(2)(L-Leu)(2)(Clo4)(2)](2)Center Dot 2h(2)O

A dinuclear copper(II) complex [Cu-2(TATP)(2)(L-Leu)(2)(ClO4)(2)](2)center dot 2H(2)O was synthesized and characterized, where, TATP=1,4,8,9-tetraazatriphenylene, and L-Leu =L-leucinate. The complex was crystallized in the triclinic space group P1, with two independent molecules in a unit cell. Two Cu(II) ions in each complex [Cu-2(TATP)(2)(L-Leu)(2)(ClO4)(2)] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cu1 or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalative mode and cleave pBR322 DNA in the presence of ascorbate.