Effect of sodium butyrate on intestinal inflammatory response to lipopolysaccharide in broiler chickens

Jiang, Y., Zhang, W., Gao, F. and Zhou, G. 2015. Effect of sodium butyrate on intestinal inflammatory response to lipopolysaccharide in broiler chickens. Can. J. Anim. Sci. 95: 389-395. The aim of this study was to investigate the effect of sodium butyrate (SB) supplementation on intestinal inflammatory response to lipopolysaccharide (LPS) in broiler chickens. A total of 120 one-day-old chickens (Arbor Acres) were divided into two groups and fed a control diet (without SB) or 1.00 g SB kg-1 diet. Half of the chickens fed each diet were injected intra-peritoneally with 0.5 g kg-1 body weight of Escherichia coli LPS at 16, 18 and 20 d of age. The results showed that the LPS challenge decreased (P<0.05) villus height and the ratio of villus height to crypt depth (V/C ratio), increased (P<0.01) crypt depth of the duodenum. SB supplementation increased (P<0.05) villus height, crypt depth and V/C ratio of the duodenum and jejunum, except for the crypt depth of the jejunum. The LPS challenge increased (P<0.05) m...