A self-hardening biodegradable cement as a drug delivery vehicle

INTRODUCTION: Injectable, resorbable cements are commonly studied for bone repair, but rarely considered as vehicles for sustained drug release in tissues other than bone. In this study, a self-hardening biodegradable calcium carbonate cement containing the drug hydroxyflutamide was developed. Hydroxyflutamide is used for treatment of pancreas cancer, which is a possible indication for this drug delivery system. Drug release measurements showed a sustained release of the drug for several days.