beta-F1-ATPase expression as a prognostic factor for resected non-small cell lung cancer

Aim : To evaluate cellular mitochondrial activity, through β-F1-ATPase expression, as an individual prognostic factor and its contribution to a multivariable prognostic survival model for resected non small cell lung cancer Methods : Mitochondrial activity (A group), clinical variables (B group), laboratory tests (C group), molecular markers (D group) and pathologic TNM descriptors (E group) were collected from 134 early-stage non small cell lung cancer patients with complete surgical resection in a consecutive four years period. Mitochondrial activity and the rest of the studied variables were first assessed by individual groups and then as a multivariable model group (MM group). Prognostic performance was analyzed by the area under the receiver operating characteristic (ROC) curve (C-index). A multivariate analysis supervised algorithm was used to perform a prognostic classification system Results: Prognostic performances of each individual group, and as well as their correlations with the MM group, are shown in Table 1 View this table: Table 1. Prognostic performance by variable groups Conclusion: This study shows that mitochondrial activity is not an effective individual prognosis factor. In association with other variables, as a multidimensional prognosis model, mitochondrial activity provides accuracy and classifies patients with higher statistical power than the rest of the separated analyzed variables.