The role of vitamin D3 in the local inflammatory process in sarcoidosis (SA)

Background: SA is an inflammatory disease characterized by granulomas that can produce 1.25(OH)2D hormone. No reports are available in the literature on the role of vitamin D3 derivatives in the local inflammation. Aims: To assess the role of vitamin D3 derivatives in the local inflammatory process in SA based on the determination of their concentration in the bronchoalveolar lavage fluid (BALF) as well as in exhaled breath condensate (EBC). Material and Methods: In 108 pts (48 women, 60 men; (mean±SD) age 44.3±9.5 yrs, BMI=27.5±4.8) with SA stage I-IV we measured 1.25(OH)2D (pg/m), 25(OH)D (ng/ml) in serum, EBC and BALF. Results: Results are shown below: View this table: Table 1 View this table: Table 2 No correlation was found between 25OHD or 1.25(OH)2D and CD8 lymphocyte count or BALF CD4/CD8. Conclusions: 1. It is possible to measure vitamin D3 derivates concentration in BALF and EBC. 2. Many correlations found between macrophage, lymphocyte and neutrophil counts in BALF and concentration of 1.25D and 25D in serum, BALF and EBC suggest an important role of vitamin D derivates in local and systemic inflammatory process in SA. Supported by: Polish Ministry of Science grant No 1594/P01/2007/32